Epilepsy

cannabinoids have excellent therapeutic potential for the treatment of epilepsy. In the brain, the endocannabinoid system tends to keep neuronal activity wihtin acceptable boundaries. More importantly, cannabinoids prevent hypersynchronisation of cortical neurons (which is the very definition of a seizure).

δ-opioid receptor

δ-opioid receptors are primarily sensitive to opioids and enkephalins. δ-opioid receptors are not classic cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on δ-opioid receptors they are effectively cannabinoid receptors.

TRPM8

TRPM8 is involved in sensory perception.

TRPA1

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.

Kv4.3

Kv4.3 is a potassium channel that is involved in the repolarisation of action potentials in cardiac muscle. Kv4.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Kv3.1

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Kv3.1 it is effectively a cannabinoid receptor.

Kv1.2

Kv1.2 is a potassium channel that is responsible for maintaining resting membrane potential and regulating excitability in neurons. Kv1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

GlyR

Glycine receptors are sensitive to glycine and produce a hyperpolarising current upon activation. GlyRs are not classic cannabinoid receptora but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on GlyRs they are effectively cannabinoid receptors.

Cav3.2

Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages. Cav3.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Cav3.1

Cav3.1 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.1 is activated by relatively low/negative voltages. Cav3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.