PEA

Suspected endocannabinoid.

OEA

Suspected endocannabinoid.

2AGE/Noladin

Suspected cannabinoid that binds to several cannabinoid receptors.

2AG

2AG is a major endocannabinoid produced from lipids in cellular membranes, mostly but not exclusively in response to cellular activity. In the brain, endocannabinoids serve mainly as negative feedback molecules (reducing presynaptic neurotransmitter release after postsynaptic activation) keeping overall brain activity in balance.

Anandamide

Anandamide was the first identified endocannabinoid, named after the Sanskrit 'ananda' for inner bliss. Anandamide is produced from lipids in cellular membranes throughout the body. In the brain, anandamide is primarily involved in negative feedback, keeping brain activity in balance. In the body, anandamide is implicated in the suppression of tumour growth, pain and vomiting and the stimulation of eating.  

DHEA

Suspected endocannabinoid. Officially a steroid hormone but binds CB1 receptors.

EPEA

Suspected endocannabinoid.

Obesity

Energy homeostasis (balance)  is one of the primary functions of the endocannabinoid system.

Epilepsy

cannabinoids have excellent therapeutic potential in epilepsy. In the brain, cannabinoids tend to keep neuronal activity wihtin acceptable boundaries. More importantly, cannabinoids prevent hypersynchronisation of cortical neurons (which is the very definition of a seizure).

Migraine

migraine is a chronic neurological disorder that is mostly characterized by severe headaches and aura.