Epilepsy

cannabinoids have excellent therapeutic potential for the treatment of epilepsy. In the brain, the endocannabinoid system tends to keep neuronal activity wihtin acceptable boundaries. More importantly, cannabinoids prevent hypersynchronisation of cortical neurons (which is the very definition of a seizure).

δ-opioid receptor

δ-opioid receptors are primarily sensitive to opioids and enkephalins. δ-opioid receptors are not classic cannabinoid receptors but their activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on δ-opioid receptors they are effectively cannabinoid receptors.

Kv3.1

Kv3.1 is a potassium channel that functions in action potential repolarisation in fast-firing neurons. Kv3.1 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids. Since cannabinoids have a physiological effect on Kv3.1 it is effectively a cannabinoid receptor.

Cav3.2

Cav3.2 is a calcium channel of the T-type that is involved in many processes in the brain and other tissues. Contrary to other calcium channels Cav3.2 is activated by relatively low/negative voltages. Cav3.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Cav3.3

Cav3.3 is a calcium channel of the T-type that is involved in many brain processes. Contrary to other calcium channels Cav3.3 is activated by relatively low/negative voltages. Cav3.3 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.

Insomnia

Insomnia is a sleep disorder characterized by inability to sleep or sleeping less time than desired. The endocannabinoid system plays a role in sleep processes and medical cannabis users already reported benefits of cannabis use to sleep.