TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.


Nav1.2 is a sodium channel that is involved in action potential generation in neurons and in muscle. Nav1.2 is not a classic cannabinoid receptor but its activity is modulated by cannabinoids.


pain is a very good target for therapeutic cannabinoids.

Klinefelter Syndrome

Klinefelter Syndrome is a disorder resulting from an extra copy of the X chromosome in males. Men with Klinefelter Syndrome are sterile and typically have reduced muscle strength, less body hair and smaller genitals and increased height, breast formation and sometimes reduced linguistic skills. As most symptoms of Klinefelter Syndrome are a direct result of increased production of X chromosomal gene products the therapeutic potential of cannabinoids is not straightforward.