CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

CB2

CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.

CBG

CBG is a non-psychoactive cannabinoid with therapeutic potential in cancer, Huntington's Disease, eating disorders, gastrointestinal inflammation, glaucoma and Psoriasis.

Pain

pain is a very good target for therapeutic cannabinoids.

α2r

α2 receptors are classically known as adrenalin receptors. However, α2 receptors also bind CBG at very high affinity and are therefore also cannabinoid receptors. The interaction between CBG and α2 receptors may be relevant in the treatment of pain and depression, but more research is required.

TRPV3

TRPV3 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

TRPA1

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.

TRPM8

TRPM8 is involved in sensory perception.

OCD

OCD is an Anxiety disorder characterised by the obsessive urge for repetitive behaviour.

Huntington's

Huntington's disease is a genetic neurodegenerative disorder, marked by preferential degeneration of neurons in the basal ganglia (caudate and putamen) and accompanied by motor deficits, cognitive impairment and psychiatric symptoms.