CB1

CB1 is the main cannabinoid receptor in the brain but is also found in other tissues. CB1 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently reduces cAMP upon activation. This in turn regulates many second messenger pathways.

Pain

pain is a very good target for therapeutic cannabinoids.

TRPM8

TRPM8 is involved in sensory perception.

α2r

α2 receptors are classically known as adrenalin receptors. However, α2 receptors also bind CBG at very high affinity and are therefore also cannabinoid receptors. The interaction between CBG and α2 receptors may be relevant in the treatment of pain and depression, but more research is required.

TRPA1

TRPA1 is best known as a sensor for environmental irritants, pain, cold and stretch.

CB2

CB2 is primarily expressed in the immune cells and tissues of the body. Like CB1, CB2 is a G protein-coupled receptor which inhibits adenylyl cyclase and consequently lowers cAMP upon activation. This, in turn, regulates many second messenger pathways.

TRPV3

TRPV3 is one of the non-GPCR-coupled cannabinoid receptors. TRPs are typically involved in pain sensation.

4-OH-5-acetoxy-CBG

4-OH-5-acetoxy-CBG is a recently discovered cannabinoid. The physiological and therapeutic properties of 4-OH-5-acetoxy-CBG remain to be investigated.

5-metoxy-CBG

5-metoxy-CBG is a recently discovered cannabinoid. The physiological and therapeutic properties of 6,7-epoxy-CBG remain to be investigated.

6,7-epoxy-CBG

6,7-epoxy-CBG is a recently discovered cannabinoid. The physiological and therapeutic properties of 6,7-epoxy-CBG remain to be investigated.