THCB and CBDB have been identified in the italian medical cannabis strain FM2. THCB showed higher binding affinity for the CB1 receptor when compared to THC binding affinity. However, binding affinity was similar for the CB2 receptor. The effects of THCB were tested in animals, showing similar effects as THC (Linciano et al., 2019).
Linciano, P., Citti, C., Luongo, L., Belardo, C., Maione, S., Vandelli, M. A., Forni, F., Gigli, G., Laganà, A., Montone, C. M., & Cannazza, G. (2019). Isolation of a High-Affinity cannabinoid for the Human CB1 Receptor from a Medicinal Cannabis sativa Variety: Δ9-Tetrahydrocannabutol, the Butyl Homologue of Δ9-Tetrahydrocannabinol. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.9b00876